Pd(<scp>ii</scp>)-Catalyzed [4 + 1 + 1] cycloaddition of simple <i>o</i>-aminobenzoic acids, CO and amines: direct and versatile synthesis of diverse <i>N</i>-substituted quinazoline-2,4(1<i>H</i>,3<i>H</i>)-diones
Xiaopeng Zhang, Qianqian Ding, Jinjun Wang, Jingyi Yang, Xuesen Fan, Guisheng Zhang
Abstract
Pd(<sc>ii</sc>)-Catalyzed modular synthesis of diverse quinazoline-2,4-(1<italic>H</italic>,3<italic>H</italic>)-diones through one-pot cascade cycloaddition of <italic>o</italic>-aminobenzoic acids with CO and amines can proceed efficiently under mild conditions in moderate to excellent yields.
Topics & Concepts
CatalysisQuinazolineCycloadditionChemistryCombinatorial chemistryMedicinal chemistryOrganic chemistryQuinazolinone synthesis and applicationsSynthesis and Biological EvaluationCatalytic C–H Functionalization Methods