Carbapenem-resistant hypervirulent Klebsiella pneumoniae: where is it headed in the tug-of-war between virulence and resistance?
Meng Wang, Hui Wang
Abstract
The emergence of carbapenem-resistant hypervirulent Klebsiella pneumoniae presents serious challenge to global public health.1 Traditionally, hypervirulent K. pneumoniae (hvKP) and carbapenem-resistant K. pneumoniae (CRKP) occupied distinct ecological niches: hvKP strains, associated with community-acquired infections such as liver abscesses and endophthalmitis, retained antibiotic susceptibility despite their high virulence, while CRKP strains, primarily responsible for hospital-acquired pneumonia and sepsis, exhibited multidrug resistance but were less virulent.
Topics & Concepts
Klebsiella pneumoniaeVirulenceMicrobiologyVirologyKlebsiella infectionsTug of warKlebsiellaCarbapenemBiologyMedicineAntibioticsGeneEscherichia coliGeneticsPhysicsAstronomyAntibiotic Resistance in BacteriaBacterial Identification and Susceptibility TestingBacteriophages and microbial interactions