Angiopep-2-decorated titanium–alloy core–shell magnetic nanoparticles for nanotheranostics and medical imaging
Senthilkumar Thirumurugan, Pranjyan Dash, Xinrui Liu, Yuan‐Yun Tseng, Wei-Jhih Huang, Yunqian Li, Gang Zhao, Ching‐Po Lin, Keerthi Murugan, Udesh Dhawan, Ren‐Jei Chung
Abstract
findings demonstrated that intravenous injection of Ti@FeAu-Ang nanoparticles exhibited a 10-fold decrement in tumor volume compared to the control group. Furthermore, immunohistochemical analysis of Ti@FeAu-Ang nanoparticles showed that coagulative necrosis of tumor tissues and preliminary safety analysis highlighted no toxicity to the haematological system, after Ti@FeAu-Ang nanoparticle-induced hyperthermia treatment.
Topics & Concepts
GliomaHyperthermiaBlood–brain barrierMagnetic hyperthermiaChemistryCancer researchIn vivoNanoparticleMaterials scienceMagnetic nanoparticlesMedicineNanotechnologyInternal medicineBiologyCentral nervous systemBiotechnologyNanoparticle-Based Drug DeliveryCharacterization and Applications of Magnetic NanoparticlesNanoplatforms for cancer theranostics