Differential effects of obesity on visceral versus subcutaneous adipose arteries: role of shear-activated Kir2.1 and alterations to the glycocalyx
Sang Joon Ahn, Elizabeth Le Master, James C. Lee, Shane A. Phillips, Irena Levitan, Ibra S. Fancher
Abstract
We identified a role for endothelial Kir2.1 in the differences observed in VAA versus SAA endothelial function with obesity. The endothelial glycocalyx, a regulator of Kir activation by shear, is unequally perturbed in VAAs as compared with SAAs, which we propose results in a near complete loss of VAA endothelial Kir shear sensitivity and endothelial dysfunction. We propose that these differences underly the preserved endothelial function of SAA in obese mice and humans.
Topics & Concepts
GlycocalyxAdipose tissueEndothelial dysfunctionEndocrinologyInternal medicineVasodilationEndotheliumBiologyChemistryMedicineImmunologyBlood properties and coagulationThermoregulation and physiological responsesCardiovascular Health and Disease Prevention