Novel fused pyridine derivatives containing pyrimidine moiety as prospective tyrosyl-tRNA synthetase inhibitors: Design, synthesis, pharmacokinetics and molecular docking studies
Ismail M. M. Othman, Mohamed A. M. Gad‐Elkareem, El Hassane Anouar, Mejdi Snoussi, Kaïss Aouadi, Adel Kadri
Topics & Concepts
ChemistryADMEMoietyDocking (animal)StereochemistryPyridineAntimicrobialPyrimidineHydrogen bondMolecular modelBenzimidazoleMorpholineActive siteProton NMRCombinatorial chemistryEnzymeIn vitroMoleculeOrganic chemistryBiochemistryNursingMedicineRNA and protein synthesis mechanismsAntimicrobial Peptides and ActivitiesBioactive Compounds and Antitumor Agents