Dupilumab: An emerging therapy in allergic fungal rhinosinusitis
Adeeb A. Bulkhi, Ahmad A. Mirza, Abdullah Jameel Aburiziza, Osama Marglani
Abstract
Allergic fungal rhinosinusitis (AFRS) is a highly resistant disease and is challenging to treat. Patients with recurrent attacks of the disease despite surgical management can benefit from biologics as adjunct therapies. Dupilumab has shown promising endpoints in patients with chronic rhinosinusitis with nasal polyposis (CRSwNP). This case series reports 4 patients with resistant AFRS concomitant with asthma, for which dupilumab therapy was administered. Long-term follow-ups showed that dupilumab improved the symptoms and improved the results of objective tools such as imaging and pulmonary function test.
Topics & Concepts
DupilumabMedicineChronic rhinosinusitisAsthmaConcomitantOmalizumabDermatologyDiseaseBenralizumabSinusitisImmunologyInternal medicineEosinophilImmunoglobulin EMepolizumabAntibodySinusitis and nasal conditionsAllergic Rhinitis and SensitizationAsthma and respiratory diseases