Directionality of HLA-DP permissive mismatches improves risk prediction in HCT for acute leukemia and MDS
Esteban Arrieta‐Bolaños, Lars L. J. van der Burg, Tobias Gedde‐Dahl, Marie Robin, Urpu Salmenniemi, Nicolaus Kröger, Ibrahim Yakoub‐Agha, Anne Huynh, Charles Crawley, Éric Deconinck, Claude‐Eric Bulabois, Édouard Forcade, Eleni Tholouli, Joost G.K. van der Hem, Peter van Balen, Jorinde D. Hoogenboom, Liesbeth C. de Wreede, Florent Malard, Annalisa Ruggeri, Katharina Fleischhauer
Abstract
ABSTRACT: HLA-DP permissive mismatches can be assigned a direction according to their immunopeptidome divergence across core and noncore subsets. Noncore permissive graft-versus-host mismatches show significantly reduced risks of relapse without increased nonrelapse mortality compared with allele-matched pairs.
Topics & Concepts
Human leukocyte antigenPermissiveMedicineLeukemiaImmunologyOncologyCancer researchInternal medicineVirologyAntigenAcute Myeloid Leukemia ResearchChronic Lymphocytic Leukemia Research