Advances in Mechanochemical C─H Functionalization: A Comparative Study with Solvent‐Based Approaches
N. Narayanan, Michael Schnürch
Abstract
Abstract This review provides an overview on recent progress in mechanochemical transition metal catalyzed C─H functionalization. Solventless operation and enhanced reaction efficiency makes mechanochemical synthesis a more sustainable alternative to conventional approaches. By including a comparison between mechanochemical methods and conventional solvent‐based protocols, this review provides chemists with valuable insights into the relative efficiency and sustainability of these solventless strategies. This comparison enables informed decision‐making when selecting methods for C─H functionalization based on specific needs. Moreover, the review identifies existing gaps in mechanochemical C─H functionalization and discusses necessary steps to establish it as a mainstream approach. By bridging these gaps, chemists can further enhance the utility and adoption of mechanochemical methodologies, contributing to more sustainable practices in synthetic chemistry.