A synergistic therapeutic nano-eyedrop for dry eye disease based on ascorbic acid-coupled exosomes
Fang Ma, Jing Feng, Xi Liu, Ying Tian, Wenjing Wang, Fuxiao Luan, Yingjie Wang, Weiqiang Yang, Jingyi Bai, Yi‐Quan Zhang, Yong Tao
Abstract
(mExo@AA). The therapeutic value of mExo@AA for DED was demonstrated in a mouse DED model. Combining the benefits of mExo and AA, mExo@AA effectively improves corneal epithelium recovery and anti-inflammation capacity, decreases corneal reactive oxygen species, and restores tear secretion without adverse effects. Thus, this study suggests that mExo@AA is effective and safe as a therapeutic agent for the treatment of DED.
Topics & Concepts
Ascorbic acidMicrovesiclesNanoparticleChemistryMembranePhospholipidColloidal goldNano-NanotechnologyBiophysicsBiochemistryMaterials scienceBiologyFood sciencemicroRNAComposite materialGeneOcular Surface and Contact LensCorneal Surgery and TreatmentsPolydiacetylene-based materials and applications