Sequential Glycosylation of Proteins with Substrate-Specific <i>N</i>-Glycosyltransferases
Lin Liang, Weston Kightlinger, Sunaina Kiran Prabhu, Adam J. Hockenberry, Chao Li, Lai‐Xi Wang, Michael C. Jewett, Milan Mrksich
Abstract
-glycans overcomes a major limitation in synthesizing defined glycoproteins for research and therapeutic applications.
Topics & Concepts
GlycosyltransferaseGlycosylationGlycoproteinMonosaccharideBiochemistryGlycanSequence (biology)ChemistryAcceptorComputational biologyProtein sequencingPeptidePeptide sequenceBiologyEnzymeGeneCondensed matter physicsPhysicsGlycosylation and Glycoproteins ResearchCarbohydrate Chemistry and SynthesisMonoclonal and Polyclonal Antibodies Research