Hypoxia Is a Dominant Remodeler of the Effector T Cell Surface Proteome Relative to Activation and Regulatory T Cell Suppression
James R. Byrnes, Amy M. Weeks, Eric Shifrut, Julia Carnevale, Lisa L. Kirkemo, Alan Ashworth, Alexander Marson, James A. Wells
Abstract
T cell surfaceome similarly responded to hypoxia, revealing a common hypoxia-induced surface receptor program. Our surfaceomics findings suggest that hypoxic environments create a challenge for T cell activation. These studies provide global insight into how Tregs and hypoxia remodel the T cell surfaceome and we believe represent a valuable resource to inform future therapeutic efforts to enhance T cell function.
Topics & Concepts
ProteomeCell biologyT cellBiologyTumor microenvironmentCD8CellImmunotherapyImmune systemEffectorCancer immunotherapyImmunologyBioinformaticsBiochemistryImmune Cell Function and InteractionImmunotherapy and Immune ResponsesCancer Immunotherapy and Biomarkers