Quantitative analysis of mRNA-lipid nanoparticle stability in human plasma and serum by size-exclusion chromatography coupled with dual-angle light scattering
Brian Liau, Li Zhang, Melgious Jin Yan Ang, Jian Yao Ng, Suresh Babu C. V., Sonja M. Schneider, Ravindra Gudihal, Ki Hyun Bae, Yi Yan Yang
Topics & Concepts
Size-exclusion chromatographyRadius of gyrationMessenger RNAChemistryScatteringDynamic light scatteringNanoparticleBiophysicsChromatographyMaterials sciencePolymerNanotechnologyBiochemistryEnzymePhysicsBiologyOpticsOrganic chemistryGeneRNA Interference and Gene DeliveryProtein purification and stabilityViral Infectious Diseases and Gene Expression in Insects