Anomanolide C suppresses tumor progression and metastasis by ubiquitinating GPX4-driven autophagy-dependent ferroptosis in triple negative breast cancer
Yanmei Chen, Wei Xu, Yang Liu, Jiahui Zhang, Yuanyuan Yang, Zhiwen Wang, Dejuan Sun, Hua Li, Bo Liu, Li-Xia Chen
Abstract
ubiquitinating GPX4, which might shed light on exploiting AC as a new drug candidate for the future TNBC therapy.
Topics & Concepts
AutophagyCancer researchTriple-negative breast cancerBiologyMetastasisCancerBreast cancerCell biologyApoptosisGeneticsFerroptosis and cancer prognosisCancer-related molecular mechanisms researchRNA modifications and cancer