Tracking the PROTAC degradation pathway in living cells highlights the importance of ternary complex measurement for PROTAC optimization
Martin P. Schwalm, Andreas Krämer, Anja Dölle, Janik Weckesser, Xufen Yu, Jian Jin, Krishna Saxena, Stefan Knapp
Topics & Concepts
Degradation (telecommunications)Ternary operationTernary complexMechanism (biology)Computer scienceBiochemical engineeringChemistryComputational biologyEngineeringBiologyBiochemistryPhysicsEnzymeProgramming languageTelecommunicationsQuantum mechanicsProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysCAR-T cell therapy research