P22077 inhibits LPS-induced inflammatory response by promoting K48-linked ubiquitination and degradation of TRAF6
Xibao Zhao, Feiyang Ji, Hongrui Li, Huihui Zhu, Zizhao Zhao, Ling Jing, Qianqian Di, Xingyu Ma, Weilin Chen
Abstract
study showed that P22077 could relieve inflammatory response and reduce the lung injury in C57BL/6 mice with LPS-induced endotoxemia. Mechanically, P22077 might play an anti-inflammatory role by promoting tumor necrosis factor receptor-associated factor 6 (TRAF6) degradation via K48-linked polyubiquitination. These findings provide a rationale for the role of the P22077 in anti-inflammatory pathway and the promising clinical application of P22077 to treat inflammatory diseases.
Topics & Concepts
InflammationUbiquitinTumor necrosis factor alphaDeubiquitinating enzymeIn vivoProinflammatory cytokineSignal transductionCancer researchNF-κBImmunologyMedicinePharmacologyChemistryCell biologyBiologyBiochemistryBiotechnologyGeneUbiquitin and proteasome pathwaysNF-κB Signaling Pathwaysinterferon and immune responses