Synthesis, in vitro, and in silico studies of morpholine-based thiosemicarbazones as ectonucleotide pyrophosphatase/phosphodiesterase-1 and -3 inhibitors
Mussarat Tasleem, Julie Pelletier, Jean Sévigny, Zahid Hussain, Ajmal Khan, Ahmed Al‐Harrasi, Attalla F. El‐kott, Parham Taslımı, Sally Negm, Zahid Shafiq, Jamshed Iqbal
Topics & Concepts
MorpholineIn silicoChemistryIsozymePhosphodiesteraseADMEDocking (animal)StereochemistryEnzymeIn vitroEnzyme kineticsActive siteBiochemistryCombinatorial chemistryOrganic chemistryMedicineGeneNursingMetal complexes synthesis and propertiesAdenosine and Purinergic SignalingHIV/AIDS drug development and treatment