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Safety, tolerability, and immunogenicity of the chimpanzee adenovirus type 3-vectored Marburg virus (cAd3-Marburg) vaccine in healthy adults in the USA: a first-in-human, phase 1, open-label, dose-escalation trial

Melinda Hamer, Katherine V. Houser, Amelia R. Hofstetter, Ana M. Ortega‐Villa, Christine Lee, Anne Preston, Brooke Augustine, Charla Andrews, Galina V. Yamshchikov, Somia P. Hickman, Steven Schech, Jack Hutter, Paul T. Scott, Paige Waterman, Mihret F. Amare, Victoria Kioko, Casey Storme, Kayvon Modjarrad, Melanie McCauley, Merlin L. Robb, Martin R. Gaudinski, Ingelise J. Gordon, LaSonji A. Holman, Alicia T. Widge, Larisa Strom, Myra Happe, Josephine H. Cox, Sandra Vazquez, Daphne A. Stanley, Tamar Murray, Caitlyn N M Dulan, Ruth Hunegnaw, Sandeep Narpala, Phillip A. Swanson, Manjula Basappa, Jagada Thillainathan, Marcelino Padilla, Britta Flach, Sarah O’Connell, Olga Trofymenko, Patricia Morgan, Emily E. Coates, Jason G. Gall, Adrian B. McDermott, Richard A. Koup, John R. Mascola, Aurélie Ploquin, Nancy J. Sullivan, Julie A. Ake, Julie E. Ledgerwood, Rebecca Lampley, Brenda Larkin, Pamela Costner, Hope Wilson, Mike Read

2023The Lancet65 citationsDOIOpen Access PDF

Topics & Concepts

ReactogenicityMarburg virusImmunogenicityMedicineAdverse effectTolerabilityVirologyVaccinationEbola virusClinical trialImmunologyAntibodyInternal medicineVirusViral Infections and Outbreaks ResearchSARS-CoV-2 and COVID-19 ResearchVirus-based gene therapy research
Safety, tolerability, and immunogenicity of the chimpanzee adenovirus type 3-vectored Marburg virus (cAd3-Marburg) vaccine in healthy adults in the USA: a first-in-human, phase 1, open-label, dose-escalation trial | Litcius