Photo-Brook rearrangement of acyl silanes as a strategy for photoaffinity probe design
Annika C. S. Page, Spencer O. Scholz, Katherine E. Near, Jessica N. Spradlin, Bridget P. Belcher, Scott M. Brittain, John A. Tallarico, Jeffrey M. McKenna, Markus Schirle, Daniel K. Nomura, F. Dean Toste
Abstract
Pr acyl silanes were shown to selectively label recombinant BRD4-BD1 and FKBP12, respectively, with minimal background. Together, these data highlight the untapped potential of acyl silanes as a novel, tunable scaffold for photoaffinity labeling.
Topics & Concepts
SilanesChemistryPhotoaffinity labelingCombinatorial chemistryStereochemistryOrganic chemistrySilaneReceptorBiochemistryClick Chemistry and ApplicationsChemical Synthesis and AnalysisSynthetic Organic Chemistry Methods