Photocontrolled activation of doubly <i>o</i>-nitrobenzyl-protected small molecule benzimidazoles leads to cancer cell death
Manzoor Ahmad, Naveen J. Roy, Anurag Singh, Debashis Mondal, Abhishek Mondal, Thangavel Vijayakanth, Mayurika Lahiri, Pinaki Talukdar
Abstract
antiport as the main ion transport process. Interestingly, double protection with photocages was found to be necessary to achieve the complete "OFF-state" that could be activated by external light. The procarriers were eventually activated inside the MCF-7 cancer cells to induce phototoxic cell death.
Topics & Concepts
ChemistryAntiporterBenzimidazolePhototoxicityCancer cellSmall moleculeCombinatorial chemistryBiophysicsProgrammed cell deathTransporterMoleculeCancerIn vitroBiochemistryApoptosisMembraneBiologyOrganic chemistryGeneticsGenePhotochromic and Fluorescence ChemistryMolecular Sensors and Ion DetectionDNA and Nucleic Acid Chemistry