Biophysical analysis of an HCN1 epilepsy variant suggests a critical role for S5 helix Met-305 in voltage sensor to pore domain coupling
Andrew Hung, Ian C. Forster, Chaseley E. McKenzie, Géza Berecki, Steven Petrou, Anirudh Kathirvel, Ming S. Soh, Christopher A. Reid
Topics & Concepts
Protein subunitXenopusBiophysicsCyclic nucleotide-binding domainChemistryMembrane potentialMutantMutationCoupling (piping)Hyperpolarization (physics)Potassium channelBiologyBiochemistryGeneStereochemistryMaterials sciencePeptide sequenceNuclear magnetic resonance spectroscopyMetallurgyIon channel regulation and functionRNA and protein synthesis mechanismsNeuroscience and Neuropharmacology Research