Preclinical Data on the <i>Gardnerella</i> -Specific Endolysin PM-477 Indicate Its Potential to Improve the Treatment of Bacterial Vaginosis through Enhanced Biofilm Removal and Avoidance of Resistance
Christine Landlinger, Vera Oberbauer, Lenka Podpera Tišáková, Timo Schwebs, Rocío Berdaguer, Leen Van Simaey, Mario Vaneechoutte, Lorenzo Corsini
Abstract
biofilms, as well as its high resilience to resistance formation, makes PM-477 a promising potential alternative for the treatment of bacterial vaginosis, especially in patients with frequent recurrence.
Topics & Concepts
MicrobiologyBacterial vaginosisGardnerella vaginalisBiofilmBiologyAntibioticsMetronidazoleBacteriaDrug resistanceClindamycinGeneticsReproductive tract infections researchBacteriophages and microbial interactionsClostridium difficile and Clostridium perfringens research