Aging and rejuvenation - a modular epigenome model
Priscila Chiavellini, Martina Canatelli-Mallat, Marianne Lehmann, Maria D. Gallardo, Claudia Beatriz Hereñú, José L. Cordeiro, James P. Clement, Rodolfo G. Goya
Abstract
, it is only able to drag the phenotype to a partially rejuvenated condition. In order to explain the results, a bimodular epigenome is proposed, where module A represents the DNAm clock component and module B the remainder of the epigenome. Epigenetic rejuvenation seems to hold the key to arresting or even reversing organismal aging.
Topics & Concepts
EpigenomedNaMReprogrammingEpigeneticsBiologyDNA methylationRejuvenationClock networkCircadian clockCountermovementComputational biologyComputer scienceNeuroscienceGeneticsClock skewCircadian rhythmCellJitterClock signalJumpTelecommunicationsPhysicsQuantum mechanicsGene expressionGeneEpigenetics and DNA MethylationGenetics and Neurodevelopmental Disorders