PERK activation by CCT020312 chemosensitizes colorectal cancer through inducing apoptosis regulated by ER stress
Yunpeng Lei, Lirui He, Yan Chang, Yuchen Wang, Guoqing Lv
Topics & Concepts
Unfolded protein responseEndoplasmic reticulumApoptosisGene knockdownCancer researchCHOPCell growthKinaseIntegrated stress responseColorectal cancerActivator (genetics)Cell biologyBiologyMedicineCancerInternal medicineTranslation (biology)ReceptorBiochemistryMessenger RNAGeneEndoplasmic Reticulum Stress and DiseaseAutophagy in Disease and TherapyCRISPR and Genetic Engineering