Regioselective construction of pyridazine and tetrahydrocinnoline derivatives <i>via</i> [4 + 2] cycloaddition–elimination with α-halogeno hydrazones and enaminones
Liancheng Duan, Xin Wang, Yu‐Cheng Gu, Yunlei Hou, Ping Gong
Abstract
Herein, we report the <italic>de novo</italic> construction of pyridazine scaffolds <italic>via</italic> a [4 + 2] cycloaddition–elimination reaction with α-halogeno hydrazones and enaminones.
Topics & Concepts
PyridazineCycloadditionChemistryRegioselectivityHydrazoneCombinatorial chemistryMedicinal chemistryOrganic chemistryCatalysisSynthesis and Reactivity of HeterocyclesCyclopropane Reaction MechanismsSynthesis and Characterization of Pyrroles