Voltage-Driven Flipping of Zwitterionic Artificial Channels in Lipid Bilayers to Rectify Ion Transport
Zhao-Jun Yan, Yawei Li, Maohua Yang, Yonghong Fu, Rongrong Wen, Wenning Wang, Zhan‐Ting Li, Yunxiang Zhang, Jun‐Li Hou
Abstract
We developed a voltage-sensitive artificial transmembrane channel by mimicking the dipolar structure of natural alamethicin channel. The artificial channel featured a zwitterionic structure and could undergo voltage-driven flipping in the lipid bilayers. Importantly, this flipping of the channel could lead to their directional alignment in the bilayers and rectifying behavior for ion transport.
Topics & Concepts
ChemistryAlamethicinLipid bilayerIon channelIon transporterBilayerTransmembrane proteinVoltage-gated ion channelVoltageIonTransmembrane channelsMembraneChannel (broadcasting)Chemical physicsOrganic chemistryBiochemistryEngineeringQuantum mechanicsReceptorElectrical engineeringPhysicsMolecular Sensors and Ion DetectionPhotoreceptor and optogenetics researchLipid Membrane Structure and Behavior