Molecular Analysis of <i>bla</i> <sub>KPC-2</sub> -Harboring Plasmids: Tn <i>4401a</i> Interplasmid Transposition and Tn <i>4401a</i> -Carrying ColRNAI Plasmid Mobilization from Klebsiella pneumoniae to Citrobacter europaeus and Morganella morganii in a Single Patient
Kayoko Sugita, Kotaro Aoki, Kohji Komori, Tatsuya Nagasawa, Yoshikazu Ishii, Satoshi Iwata, Kazuhiro Tateda
Abstract
Plasmid transfer plays an important role in the interspecies spread of carbapenemase genes, including the Klebsiella pneumoniae carbapenemase (KPC)-coding gene, bla KPC . We conducted whole-genome sequencing (WGS) analysis and transmission experiments to analyze bla KPC-2 -carrying mobile genetic elements (MGEs) between the bla KPC-2 -harboring K. pneumoniae , Citrobacter europaeus , and Morganella morganii strains isolated from a single patient. bla KPC-2 was contained within an MGE, Tn 4401a .
Topics & Concepts
PlasmidCitrobacter freundiiKlebsiella pneumoniaeMorganella morganiiMicrobiologyBiologyTransposition (logic)CitrobacterHorizontal gene transferVirologyEnterobacteriaceaeMinionGeneticsWhole genome sequencingComplete sequenceGeneAntibiotic Resistance in BacteriaNosocomial Infections in ICUInfections and bacterial resistance