Development of bivalent triarylalkene- and cyclofenil-derived dual estrogen receptor antagonists and downregulators
Alexandra Katarina Knox, Christina Kalchschmid, Daniela Schuster, Francesca Gaggìa, Claudia Manzl, Daniel Baecker, Ronald Gust
Topics & Concepts
ChemistryCoactivatorEstrogen receptorTransactivationPharmacologyEstrogenCooperative bindingNuclear receptor coactivator 1Nuclear receptorReceptorCancer researchTranscription factorBinding siteBiochemistryInternal medicineCancerBreast cancerBiologyMedicineGeneEstrogen and related hormone effectsBioactive Compounds and Antitumor AgentsComputational Drug Discovery Methods