Natural bioactive compounds in Alzheimer's disease: From the perspective of type 3 diabetes mellitus
Juan Huang, Nanqu Huang, Qianhua Mao, Jingshan Shi, Yu Qiu
Abstract
There is a close relationship between Alzheimer's disease (AD) and diabetes mellitus (DM), and the link between the two is often referred to as type 3 diabetes mellitus (T3DM). Many natural bioactive compounds have shown the potential to treat AD and diabetes. We mainly review the polyphenols represented by resveratrol (RES) and proanthocyanidins (PCs) and alkaloids represented by berberine (BBR) and Dendrobium nobile Lindl. alkaloids (DNLA) from the perspective of T3DM to review the neuroprotective effects and molecular mechanisms of natural compounds in AD.
Topics & Concepts
Type 2 Diabetes MellitusDiabetes mellitusResveratrolNeuroprotectionBerberineType 2 diabetesDiseaseMedicinePolyphenolTraditional medicinePharmacologyChemistryInternal medicineBiochemistryEndocrinologyAntioxidantBiological and pharmacological studies of plantsNeuroinflammation and Neurodegeneration MechanismsSirtuins and Resveratrol in Medicine