Molecular Determinants of Tissue Specificity of Flavivirus Nonstructural Protein 1 Interaction with Endothelial Cells
Nicholas T. N. Lo, Susan Z. Roodsari, Nicole L. Tin, Marcus P. Wong, Scott B. Biering, Eva Harris
Abstract
and cause vascular leak in a mouse model. We identified the wing domain of NS1 as a primary determinant conferring differential endothelial dysfunction and vascular leak and narrowed the contributing amino acid residues to a three-residue motif within the wing domain. The insights from this study pave the way for future studies on the effects of flavivirus NS1 on viral dissemination and pathogenesis and offer potential new avenues for antiviral therapies.
Topics & Concepts
BiologyFlavivirusVirologyCell biologyMolecular biologyBiochemistryGeneticsVirusMosquito-borne diseases and controlViral Infections and Vectorsinterferon and immune responses