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Somatic loss of the remaining allele occurs approximately in half of CHEK2-driven breast cancers and is accompanied by a border-line increase of chromosomal instability

Aglaya G. Iyevleva, Svetlana N. Aleksakhina, Anna P. Sokolenko, S. Baskina, Aigul R. Venina, Elena I. Anisimova, Ilya V. Bizin, Alexandr O. Ivantsov, Yana V. Belysheva, Alexandra P. Chernyakova, Alexandr V. Togo, Evgeny N. Imyanitov

2022Breast Cancer Research and Treatment15 citationsDOI

Topics & Concepts

CHEK2Loss of heterozygosityBiologyAlleleGermlineGeneticsChromosome instabilityGermline mutationGenome instabilityBreast cancerCancer researchMutationCancerGeneDNA damageDNAChromosomeBRCA gene mutations in cancerBreast Cancer Treatment StudiesMale Breast Health Studies
Somatic loss of the remaining allele occurs approximately in half of CHEK2-driven breast cancers and is accompanied by a border-line increase of chromosomal instability | Litcius