Plasma miRNA profile at COVID-19 onset predicts severity status and mortality
Asier Fernández-Pato, Ana Virseda‐Berdices, Salvador Resino, Pablo Ryan, Óscar Martínez-Nieto, Felipe Pérez‐García, María Martin‐Vicente, Daniel Valle‐Millares, Oscar Brochado‐Kith, Rafael Blancas, Amalia Martínez, Francisco C. Ceballos, Sofía Bartolomé‐Sanchez, Erick Joan Vidal-Alcántara, David Alonso, Natalia Blanca‐López, Ignacio Ramirez Martinez-Acitores, Laura Martín‐Pedraza, María Ángeles Jiménez‐Sousa, Amanda Fernández‐Rodríguez
Abstract
BACKGROUND: MicroRNAs (miRNAs) have a crucial role in regulating immune response against infectious diseases, showing changes early in disease onset and before the detection of the pathogen. Thus, we aimed to analyze the plasma miRNA profile at COVID-19 onset to identify miRNAs as early prognostic biomarkers of severity and survival. METHODS AND RESULTS: = 0.042). CONCLUSIONS: SARS-CoV-2 infection deeply disturbs the plasma miRNome from an early stage of COVID-19, making miRNAs highly valuable as early predictors of severity and mortality.