Involvement of TCF7L2 in generation of morphine-induced antinociceptive tolerance and hyperalgesia by modulating TLR4/ NF-κB/NLRP3 in microglia
Jing Chen, Guonian Wang, Tingting Sun, Chao Ma, Xing Huo, Yiran Kong
Topics & Concepts
MorphineAgonistMicrogliaPharmacologyDownregulation and upregulationNeuropathic painTLR4OpioidMedicineTCF7L2AnalgesicHyperalgesiaNociceptionReceptorChemistryInflammationImmunologyInternal medicineBiochemistrySingle-nucleotide polymorphismGeneGenotypeNeuropeptides and Animal PhysiologyNeuroinflammation and Neurodegeneration MechanismsImmune Response and Inflammation