Cyto-friendly polymerization at cell surfaces modulates cell fate by clustering cell-surface receptors
Jing Qi, Weishuo Li, Xiaoling Xu, Feiyang Jin, Di Liu, Yan Du, Yan Du, Jun Wang, Xiaoying Ying, Jian You, Yongzhong Du, Yongzhong Du, Jiansong Ji
Abstract
ammonium peroxysulfate (APS), the macromer bound onto the Raji cell surface polymerized, inducing the clustering of CD20 receptors, and thereby triggering cell apoptosis. This cell-surface polymerization induced cell-surface receptor crosslinking could alternatively be applied in modulating the fates and functions of other cells, especially those mediated by the spatial distribution of cell-surface receptors, such as T cell activation. Our work opens new possibilities in the area of chemical biology to some extent.
Topics & Concepts
CellReceptorPolymerizationCell biologyChemistryCell surface receptorCluster analysisBiophysicsBiochemistryBiologyComputer sciencePolymerOrganic chemistryMachine learningCell Adhesion Molecules ResearchNanoparticle-Based Drug DeliveryCellular Mechanics and Interactions