Islet amyloid polypeptide aggregation exerts cytotoxic and proinflammatory effects on the islet vasculature in mice
Joseph Castillo, Alfred C. Aplin, Daryl J. Hackney, Meghan F. Hogan, Nathalie Esser, Andrew T. Templin, Rehana Akter, Steven E. Kahn, Daniel P. Raleigh, Sakeneh Zraika, Rebecca L. Hull
Topics & Concepts
IsletProinflammatory cytokineViability assayAmyloid (mycology)ChemistryEndocrinologyInternal medicineGenetically modified mouseAmylinBeta cellEndothelial stem cellCell biologyInflammationBiologyTransgeneCellDiabetes mellitusBiochemistryMedicineIn vitroGeneInorganic chemistryAlzheimer's disease research and treatmentsPancreatic function and diabetesDiabetes and associated disorders