miR-21 mimic blocks obesity in mice: A novel therapeutic option
Said Lhamyani, Adriana‐Mariel Gentile, Rosa M. Giráldez‐Pérez, Mónica Feijoo‐Cuaresma, Silvana Y. Romero-Zerbo, Mercedes Clemente‐Postigo, Hatem Zayed, Wilfredo Oliva‐Olivera, Francisco J. Bermúdez‐Silva, J. M. Ian Salas, Carlos Lopez‐Gómez, Abdelkrim Hmadcha, Nabil Hajji, Gabriel Olveira, Francisco J. Tinahones, Rajaa El Bekay
Abstract
treatment with the miR-21 mimic blocked weight gain induced by a high-fat diet in obese mice, without modifying food intake or physical activity. This was associated with metabolic enhancement, WAT browning, and brown adipose tissue (AT) thermogenic programming through vascular endothelial growth factor A (VEGF-A), p53, and transforming growth factor β1 (TGF-β1) signaling pathways. Our findings suggest that miR-21 mimic-based therapy may provide a new opportunity to therapeutically manage obesity and consequently, its associated alterations.