Resin-free peptide synthesis mediated by tri(4-benzoylphenyl) phosphate (TBP) derivatives as small-molecule supports
Haidi Li, Jie Chao, Guang Tian, Jaafar Hasan, Yatao Jin, Zixin Zhang, Chuanguang Qin
Abstract
A series of novel tri(4-benzoylphenyl) phosphate (TBP) derivatives with unique precipitation-inducing properties were synthesized and used as C-terminal protecting groups of amino acids and recyclable supports in peptide synthesis.
Topics & Concepts
ChemistryPhosphatePeptideMoleculeCombinatorial chemistryStereochemistryPhosphate buffered salineProtecting groupPeptide synthesisAmino acidOrganic chemistryBiochemistryChromatographyAlkylChemical Synthesis and AnalysisFluorine in Organic ChemistrySynthesis and Catalytic Reactions