Polyphosphate degradation by Nudt3-Zn2+ mediates oxidative stress response
Bàrbara Samper-Martín, Ana Sarrias, Blanca Lázaro, Marta Pérez-Montero, Rosalía Rodríguez‐Rodríguez, Mariana P.C. Ribeiro, Aitor Bañón, Donald J. Wolfgeher, Henning J. Jessen, Berta Alsina, Josep Clotet, Stephen J. Kron, Adolfo Saiardi, Javier Jiménez, Samuel Bru
Abstract
is present. Nudt3 has in vivo polyP phosphatase activity in human cells, and importantly, we show that cells with altered polyP levels by modifying Nudt3 protein amount present reduced viability upon oxidative stress and increased DNA damage, suggesting that polyP and Nudt3 play a role in oxidative stress protection. Finally, we show that Nudt3 is involved in the early stages of embryo development in zebrafish.
Topics & Concepts
PolyphosphateOxidative stressZebrafishPhosphataseAlkaline phosphataseEnzymeBiologyBiochemistryCell biologyOxidative phosphorylationDNA damageInflammationPhosphateGeneDNAImmunologyCoagulation, Bradykinin, Polyphosphates, and AngioedemaVitamin K Research StudiesParathyroid Disorders and Treatments