C(sp<sup>2</sup>)–H functionalization in non-aromatic azomethine-based heterocycles
Alexey A. Akulov, Михаил В. Вараксин, Pieter Mampuys, Valery N. Charushin, Олег Н. Чупахин, Bert U. W. Maes
Abstract
Direct C(sp2)-H functionalization of the endocyclic azomethine and aldonitrone moieties in non-aromatic azaheterocycles has established itself as a promising methodology over the last decade. Transition metal-catalyzed cross-coupling reactions, α-metalation-electrophile quenching protocols, and (metal-free) nucleophilic substitution of hydrogen reactions (SNH) are the major routes applied on cyclic imines and their derivatives. In this overview, we show the tangible progress made in this area during the period from 2008 to 2020.
Topics & Concepts
Surface modificationAldimineChemistryCombinatorial chemistryOrganic chemistryCatalysisPhysical chemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsOxidative Organic Chemistry Reactions