Aculeatones A and B, epimeric lovastatin derivatives with a 6/6/3-tricyclic carbon skeleton from <i>Aspergillus aculeatus</i> and their chemical transformation
Fei Liu, Feng‐Qing Wang, Qin Li, Bingbing Dai, Weiguang Sun, Jianguo Li, Chunmei Chen, Yonghui Zhang, Hucheng Zhu
Abstract
Lovastatin derivatives aculeatones A–F (1–6) with lipid-lowering activity were isolated from Aspergillus aculeatus . 1 and 2 represent the first examples with a 6/6/3-tricyclic scaffold and the biomimetic formation of 1 was achieved starting from 3.
Topics & Concepts
ChemistryTricyclicLovastatinCarbon skeletonStereochemistryTransformation (genetics)Organic chemistryBiochemistryCholesterolGeneMicrobial Natural Products and BiosynthesisMicrobial Metabolism and ApplicationsMarine Sponges and Natural Products