Intrathecal Synthesis Index of Specific Anti- <i>Treponema</i> IgG: a New Tool for the Diagnosis of Neurosyphilis
Chloé Alberto, Christine Deffert, Nathalie Lambeng, Gautier Bréville, Angèle Gayet‐Ageron, Patrice H. Lalive, Laurence Toutous Trellu, Lionel Fontao
Abstract
In the context of a lack of a gold standard for the diagnosis of neurosyphilis due to either nonspecific or nonsensitive tests, we present in this article a new promising tool highly specific for NS diagnosis. This new test involves measuring an intrathecal synthesis index of specific anti- Treponema IgG by ELISA.
Topics & Concepts
NeurosyphilisMedicineSerologyTreponemaGastroenterologyInternal medicineConfidence intervalCerebrospinal fluidArea under the curveAntibodyImmunologyReceiver operating characteristicSyphilisHuman immunodeficiency virus (HIV)Syphilis Diagnosis and TreatmentReproductive tract infections researchFemale Genital Mutilation/Cutting Issues