Demineralized Bone Matrix and Fibers in Spinal Fusion
Joshua Wang, Ryan G. Eaton, Markus E. Harrigan, Vikas Munjal, Katelyn Sette, Seth Wilson, Andrew J. Grossbach
Abstract
Formation of bony fusion after arthrodesis depends on osteoinduction, osteoconduction, and osteogenesis. Traditionally, the patient's own bone, or autograft, has been used to provide biological material necessary for these steps. However, the amount of autograft obtainable is often inadequate. Modern spine surgery has adopted the use of many autograft extenders or replacements, such as demineralized bone matrix or fibers. The present article covers the history of bone grafting, the production and technical details of demineralized bone matrix, and the evidence supporting its use in spine fusions.
Topics & Concepts
Demineralized bone matrixMedicineArthrodesisBone graftingSpinal fusionDentistryBone morphogenetic proteindBmMatrix (chemical analysis)SurgeryBiomedical engineeringMaterials sciencePathologyComposite materialBiologyAmplifierGeneAlternative medicineCMOSOptoelectronicsBiochemistryBone Tissue Engineering MaterialsSpine and Intervertebral Disc PathologyMedical Imaging and Analysis