Trifluoro-icaritin alleviates chronic inflammatory pain through α7nAChR-mediated suppression of HMGB1/NF-κB signaling in the spinal cord of rats
Yalan Sun, Dandan Jia, Meng Xue, Zhihua Huang, Cheng Huang
Topics & Concepts
NeuroinflammationSpinal cordNeuropathic painMedicinePharmacologyAllodyniaMethyllycaconitineNociceptionHyperalgesiaHMGB1Chronic painInflammationCholinergicWestern blotAnesthesiaEndocrinologyInternal medicineNicotinic acetylcholine receptorReceptorChemistryNicotinic agonistPsychiatryGeneBiochemistryPain Mechanisms and TreatmentsNeuropeptides and Animal PhysiologyNatural product bioactivities and synthesis