Human Cytomegalovirus IE1 Impairs Neuronal Migration by Downregulating Connexin 43
Shengnan Huang, Yu‐Ting Pan, Yue‐Peng Zhou, Xian-Zhang Wang, Meng‐Jie Mei, Bo Yang, Dong Li, Wenbo Zeng, Shuang Cheng, Jinyan Sun, Han Cheng, Fei Zhao, Min‐Hua Luo
Abstract
Congenital CMV (cCMV) infection causes neurological sequelae in newborns. Recent studies of cCMV pathogenesis in animal models reveal ventriculomegaly and cortical atrophy associated with impaired neural progenitor cell (NPC) proliferation and migration.
Topics & Concepts
BiologyCell biologyConnexinHuman cytomegalovirusEctopic expressionVirologyImmunologyGap junctionCell cultureIntracellularVirusGeneticsCytomegalovirus and herpesvirus researchHerpesvirus Infections and TreatmentsRNA regulation and disease