pH/glutathione-responsive release of SO<sub>2</sub> induced superoxide radical accumulation for gas therapy of cancer
Rui Gu, Lei Wang, Xiaoyu Huang, Jiayao Zhang, Changjin Ou, Weili Si, Jian‐Guang Yu, Wenjun Wang, Xiaochen Dong
Abstract
A pH/GSH-responsive SO2 generation nanoplatform (BODS NPs) is established to achieve lysosomal escape and GSH depletion in tumor cells. O2˙- as the main ROS during SO2-mediated gas therapy can be accumulated through Cu/Zn-SOD enzymatic activity suppression and mitochondrial biogenesis, further exacerbating the oxidative stress and resulting in cell apoptosis.
Topics & Concepts
GlutathioneChemistryOxidative stressSuperoxideCancer therapyCancerOxidative damageBiophysicsBiochemistryInternal medicineMedicineEnzymeBiologyNanoplatforms for cancer theranosticsHeme Oxygenase-1 and Carbon MonoxideSulfur Compounds in Biology