Immune Repertoire Profiling Reveals Its Clinical Application Potential and Triggers for Neuromyelitis Optica Spectrum Disorders
Miao Yu, Ziyan Shi, Wei Zhang, Lin Zhu, Shanshan Tang, Hongxi Chen, Xiaofei Wang, Qin Du, Shuai Cheng Li, Ying Zhang, Wenqin Luo, Xin Jin, Mingyan Fang, Hongyu Zhou
Abstract
BACKGROUND AND OBJECTIVES: Neuromyelitis optica spectrum disorders (NMOSD) is widely recognized as a CNS demyelinating disease associated with AQP4-IgG (T cell-dependent antibody), and its trigger is still unclear. In addition, although the treatment of NMOSD currently can rely on traditional immunosuppressive and modulating agents, effective methods to predict the efficacy of these therapeutics are lacking. METHODS: NMOSD. RESULTS: NMOSD may be associated with CMV infection, which was further corroborated by transcriptome and single-cell BCR analysis results from public databases and T-cell activation experiments. DISCUSSION: NMOSD and provides a theoretical foundation for treating and monitoring the disease.