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The Transient Receptor Potential Vanilloid Type 2 (TRPV2) Channel–A New Druggable Ca2+ Pathway in Red Cells, Implications for Red Cell Ion Homeostasis

Stéphane Égée, Lars Kaestner

2021Frontiers in Physiology20 citationsDOIOpen Access PDF

Abstract

with the channels agonists 9-THC and CBD, but the authors found in agreement with previous investigations (Chari-Bitron and Shahar, 1979) a cell swelling/overhydration. The explanation of this effect remains completely elusive, although we propose an initial concept of a mechanism (see below:

Topics & Concepts

Transient receptor potential channelDruggabilityTRPVIon channelReceptorTRPM2ChemistryCell biologyHomeostasisRed CellMedicineTRPV1BiochemistryBiologyInternal medicineGeneErythrocyte Function and PathophysiologyIon Channels and ReceptorsNeonatal Health and Biochemistry
The Transient Receptor Potential Vanilloid Type 2 (TRPV2) Channel–A New Druggable Ca2+ Pathway in Red Cells, Implications for Red Cell Ion Homeostasis | Litcius