Ginsenoside Rb1 inhibits cardiomyocyte apoptosis and rescues ischemic myocardium by targeting Caspase-3
Chenhui Zhong, Liyuan Ke, Fen Hu, Zuan Lin, Shuming Ye, Ziyao Zheng, Shengnan Han, Zan Lin, Yuying Zhan, Hu Yan, Peiying Shi, Wen Lei, Hong Yao
Abstract
• Virtual screening was performed to predict the targets of Rb 1 against MI. • Proteomics, CETSA, MD simulation, etc. were used to explore the targets. • Rb 1 does not affect the cleavage of upstream protein Caspase-9 of CASP3. • Rb 1 inhibits CASP3 cleavage by binding to two His121 sites in CASP3. • Rb 1 exerts anti-MI effect via directly targeting CASP3.
Topics & Concepts
ChemistryApoptosisGinsenosideGinsenoside Rg1Cell biologyCaspase 3Caspase 8BiochemistryProgrammed cell deathGinsengBiologyAlternative medicineMedicinePathologyGinseng Biological Effects and ApplicationsTraditional Chinese Medicine AnalysisAutophagy in Disease and Therapy