Rapid, Ultrasensitive, and Quantitative Detection of SARS-CoV-2 Using Antisense Oligonucleotides Directed Electrochemical Biosensor Chip
Maha Alafeef, Ketan Dighe, Parikshit Moitra, Dipanjan Pan
Abstract
., SARS-CoV, MERS-CoV, or negative COVID-19 samples collected from healthy subjects). The feasibility of the sensor even during the genomic mutation of the virus is also ensured from the design of the ssDNA-conjugated AuNPs that simultaneously target two separate regions of the same SARS-CoV-2 N-gene.
Topics & Concepts
BiosensorOligonucleotideVirologySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Detection limitCoronavirusCoronavirus disease 2019 (COVID-19)Molecular beaconReal-time polymerase chain reactionNanotechnologyMaterials scienceChemistryBiologyMedicineChromatographyGeneInfectious disease (medical specialty)DiseaseBiochemistryPathologyAdvanced biosensing and bioanalysis techniquesSARS-CoV-2 detection and testingBiosensors and Analytical Detection