A new immuno-oncology target – SUMOylation
Yuan Chen
Abstract
Immunotherapy has been a paradigm shift in cancer treatment to produce durable responses. Unfortunately, most cancers do not respond to current immunotherapies, and thus, exploring novel mechanisms is crucial. Emerging data now demonstrate that protein modification by the small ubiquitin-like modifiers (SUMO) is a novel target to activate antitumor immunity.
Topics & Concepts
SUMO proteinImmunotherapyImmune systemBiologyCancer immunotherapyCancer researchImmunologyUbiquitinGeneGeneticsUbiquitin and proteasome pathwaysPeptidase Inhibition and AnalysisImmunotherapy and Immune Responses