From mini-puberty to pre-puberty: early impairment of the hypothalamus–pituitary–gonadal axis with normal testicular function in children with non-mosaic Klinefelter syndrome
Matteo Spaziani, S. Granato, Natascia Liberati, Fábio Rossi, Natascia Tahani, Carlotta Pozza, Daniele Gianfrilli, Giampaolo Papi, Antonella Anzuini, Andrea Lenzi, Luigi Tarani, A. Radicioni
Topics & Concepts
EndocrinologyInternal medicineTestosterone (patch)Hypothalamic–pituitary–gonadal axisKlinefelter syndromeSex hormone-binding globulinMedicinePopulationHormonePrecocious pubertyHypothalamic diseaseDelayed pubertyLuteinizing hormoneAndrogenHypogonadotropic hypogonadismEnvironmental healthGenetic and Clinical Aspects of Sex Determination and Chromosomal AbnormalitiesHypothalamic control of reproductive hormonesSexual Differentiation and Disorders